Find the best value for your money. Ignore the forums and talk to people you know. Use your local airports. Remain flexible because better deals may pop up at a moments notice. Compare different travel sites and seats. Buy at the best time.
Take care of animals and call the kennel or family members. Set up "Stop" orders for deliveries, such as mail and newspapers. Make sure you have money for your adventure both in cash and electronically. Plan your first and last days as travel days. Check the weather. Research the destination.
Check your insurance coverage for the destination you are traveling to. Have your health insurance identification with you. Medicare does not provide coverage outside the US. Bring your Passport and make sure it is filled out correctly. Have pre-existing illnesses in a letter from your health provided. Bring all necessary medications.
It is better to use a mixture of credit/debit cards and cash. Some businesses will not accept credit cards. It may be better to use credit cards to book your hotels. Check the insurance provided with your credit card company on any purchases.